The territory where the city of Dneprodzerzhinsk is located today, belongs to five sites of Ukraine, occupied by the people during the Paleolith epoch (100-40 millennium BC). During the Kiev Russian period the territory of the future Dneprodzerzhinsk, important trading occurred with the Varangians from Greece. According to the legend, the Ukrainian Cossacks played an important role in the city’s formation. The villages Romankovo and Kamenskoye, on which place Dneprodzerzhinsk is located, were founded by the Zaporozhye Cossacks. The first written mention of village Kamenskoye is dated 1750. In New Sechi (1734-1775) Kamenskoye was a part of Kodatsk of the Army Zaporozhye.
Building (1887-1889) by Polish, Belgian and French shareholders of Dneprovsky metal works on the land of the village Kamenskoye, redeemed at rural association, led to fast growth of the village. In the end of XIX – the XX-th century beginning settlements for employees and workers of factory – the Top and Bottom colonies grew. In 1896 there were 18 thousand inhabitants in Kamenskoy, and by 1913, the village had grown to 40407. In June, 1917 the Provisional government gave the village Kamenskoye the status of a city. On February, 1st, 1936 Kamenskoye was renamed Dneprodzerzhinsk. In 1938 its structure included villages Romankovo and Trituznoe. In days of industrialisation 1930-1950 in Dneprodzerzhinsk boiler-welding, nitrogen-mineral, cement and concrete factories, garment factory, car-building and a number of other enterprises were constructed.